Our Research

We work at the interface of chemistry and biology, assembling small-molecules through organic synthesis to facilitate biological studies. Specifically, we are interested in using light and enzymatic activity to unmask molecules with high spatial and/or temporal resolution. Our interaction with biologists, biochemists, and engineers at Janelia Farm Research Campus provides a rich environment to develop chemical tools to “shed light” on complex biological systems.

Open Positions
We seek talented synthetic organic chemists with a desire to use chemical methodologies to tackle biological problems. Although space is limited, individuals seeking a post-doctoral position are free to apply at anytime via email. In addition, Janelia Farm provides opportunities for visiting scientists and students to work in the lab for fixed periods of time and on defined projects. Send inquiries for such possibilities directly to the lab by email.

The Janelia Undergraduate Scholars program provides a unique opportunity for undergraduates. Interested students are encouraged to apply.

Recent Publications
Yatzeck, M. M.; Lavis, L. D.; Chao, T.-Y.; Chandran, S. S.; Raines, R. T. A highly sensitive fluorogenic probe for cytochrome P450 activity in live cells. Bioorg. Med. Chem. Lett. 2008, in press. Link

Lavis, L. D. Ester bonds in prodrugs. ACS Chem. Biol. 2008, 3, 203–206. Link

Lavis, L. D.; Raines, R. T. Bright ideas for chemical biology. ACS Chem. Biol. 2008, 3, 142–155. Link